Interactions between corticosteroids and beta agonists

Corticosteroids and erythropoeitin-receptor agonists.

Long-acting beta-agonists with and without inhaled corticosteroids and catastrophic asthma events.

BACKGROUND It is unclear whether long-acting beta-agonists with concomitant inhaled corticosteroids increase asthma-related intubations and deaths. We pooled data on long-acting beta-agonists with variable and concomitant inhaled corticosteroids to evaluate the risk for catastrophic asthma events. METHODS We conducted searches of electronic databases, the US Food and Drug Administration websi...

The benefits of combined treatment with corticosteroids and long-acting beta agonists

The benefits of combined treatment with corticosteroids and long-acting beta agonists Guidelines for the treatment of COPD recommend that long-acting beta agonists (LABA) are used initially to maximize lung function and relieve symptoms in patients with mild to moderate disease who are being treated with short-acting bronchodilators (www.goldcopd.com). Inhaled corticosteroid (ICS) therapy reduc...

Combined Beta-Agonists and Corticosteroids Do Not Inhibit Extracellular Matrix Protein Production In Vitro

Background. Persistent asthma is characterized by airway remodeling. Whereas we have previously shown that neither β(2)-agonists nor corticosteroids inhibit extracellular matrix (ECM) protein release from airway smooth muscle (ASM) cells, the effect of their combination is unknown and this forms the rationale for the present study. Methods. ASM cells from people with and without asthma were sti...

Prescribing of long-acting beta-2-agonists/inhaled corticosteroids after the SMART trial

BACKGROUND After the SMART trial evaluating the safety of salmeterol (long-acting beta-2-agonist (LABA)) in asthma patients, regulatory actions were taken to promote a guideline-adherent prescribing of LABA only to patients receiving inhaled corticosteroids (ICS). We aim to analyse LABA- and ICS-related prescription patterns after the SMART trial in Germany. METHODS Patients documented in the...